Sodium Carbonate → Hydrochloric Acid

HRID 977210

Reaktionsgleichung

Reaktionsgleichung von HRID 977210
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([C:14]([OH:16])=[O:15])[O:11][C:10]2=[O:17])=[CH:5][CH:4]=1)#[N:2].[Cl-:18].[OH:19][NH3+:20].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[ClH:18].[ClH:18].[NH2:2][C:1](=[N:20][OH:19])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:13][CH:12]([C:14]([OH:16])=[O:15])[O:11][C:10]2=[O:17])=[CH:7][CH:8]=1

Komponenten

7

Edukt 3

HCID 10340Sodium CarbonateHCID 21645Hydroxylamine HClHCID 153409393-(4-Cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid

Produkt 2

HCID 313Hydrochloric AcidHCID 131719938HCID 131719938, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

27.9 g of 3-(4-cyanophenyl)-2-oxo-5-oxazolidine carboxylic acid [obtainable according to Example 1] and 26.4 g of hydroxylammonium chloride are boiled for 5 h in a mixture of 750 ml of methanol and 30 ml of water in the presence of 53.4 g of sodium carbonate. The precipitate formed is filtered off with suction, washed with methanol and dried. Treatment with hydrochloric acid gives 3-[4-(amino(hydroxylimino)methyl)phenyl]-2-oxo-5-oxazolidinecarboxylic acid, hydrochloride, m.p. 205°-208°.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationis filtered off with suction
  3. washwashed with methanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ebafdefec83f481baf0af317c189a8f8
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05614535

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