Acetic Acid → 7-(2-Aminopyrimidin-4-yl)-1-ethyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid

HRID 978520Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 978520
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][C:11]([C:18]([CH:20]=[CH:21]N(C)C)=O)=[C:12]([F:17])[CH:13]=2)[N:8]([CH2:25][CH3:26])[CH:7]=1)=[O:5])C.Cl.[NH2:28][C:29]([NH2:31])=[NH:30].CC(C)([O-])C.[K+].C(O)(=O)C>C(O)(C)(C)C>[NH2:30][C:29]1[N:31]=[C:18]([C:11]2[CH:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[CH2:25][CH3:26])=[CH:13][C:12]=2[F:17])[CH:20]=[CH:21][N:28]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 5742Guanidine HydrochlorideHCID 23665647Potassium tert-butoxideHCID 540574497-(2'-Dimethylaminoethenyl)carbonyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Produkt 1

HCID 4614397-(2-Aminopyrimidin-4-yl)-1-ethyl-6-fluoro-4-oxo-quinoline-3-carboxylic acidAusbeute 35,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel2×

Versuchsvorschrift

To 900 mg (2.5 mmol) of the 7-(2'-dimethylaminoethenyl)carbonyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester in 15 ml of t-butanol at 50° C. was added 580 mg (2.5 eq) of guanidine hydrochloride that had been previously treated with 1.35 g (5 eq) of potassium t-butoxide at 50° C. in t-butanol for 30 minutes. The final mixture was stirred for 24 hours at 60° C. It was poured into 8% aqueous acetic acid and extracted into chloroform. The chloroform was extracted three times with water. The chloroform was dried magnesium sulfate and concentrated. The residue was purified by column chromatography and gave 295 mg of 7-(2-amino-4-pyrimidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 245°-247° C.

Aufarbeitung

  1. extractionextracted into chloroform
  2. extractionThe chloroform was extracted three times with water
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-40f26357691841a7a988914998e33e57
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04665079

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