Water → chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide

HRID 979228

Reaktionsgleichung

Reaktionsgleichung von HRID 979228
[Cl:1][C:2]1[C:3]([O:5][C:6](=[O:8])[CH:7]=1)=[O:4].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][NH2:19].O>C(O)(=O)C>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][N:19]=[C:3]([OH:4])/[C:2](/[Cl:1])=[CH:7]\[C:6]([OH:5])=[O:8]

Komponenten

5

Edukt 3

HCID 962WaterHCID 66772Chloromaleic anhydrideHCID 748962-Methoxyphenethylamine

Produkt 1

HCID 178489456chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imideAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

13.25 g (0.1 mol) of chloromaleic anhydride and 15.2 g (0.1 mol) of 2-(2-methoxyphenyl)-ethylamine are heated to the boiling point in 100 ml of glacial acetic acid for 4 hours. 100 ml of water are then added and the oil which has precipitated is extracted with methylene chloride. The methylene chloride phase is separated off, washed with water, dried and evaporated. The oil which remains crystallizes. 20.8 g (78% of theory) of chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide are obtained.

Aufarbeitung

  1. customthe oil which has precipitated
  2. extractionis extracted with methylene chloride
  3. customThe methylene chloride phase is separated off
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customThe oil which remains crystallizes

Quellen und Nachweise

ORD-Eintrag
ord-33887f723c6e4b00a2adcfa2a364aa5b
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04666935

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