3-Nitrobenzenesulfonic acid → 6-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

HRID 979283

Reaktionsgleichung

Reaktionsgleichung von HRID 979283
[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Na].[N+](C1C=C(S(O)(=O)=O)C=CC=1)([O-])=O.[OH-].[Na+]>C(O)(=O)C.O>[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Komponenten

7

Edukt 4

HCID 73873-Nitrobenzenesulfonic acidHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 131167414.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

Produkt 1

HCID 133702416-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

20 g of 4.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (EP No. 71 059, Example 1) are stirred under reflux together with 19.5 g of the sodium salt of 3-nitrobenzenesulfonic acid and 13.5 g of sodium hydroxide in b 250 ml of water for 1 hour. Thereafter, while the solution is still hot, acetic acid are added until pH 6.9. The solid material precipitated after cooling is filtered of with suction, washed with water and dried.

Aufarbeitung

  1. customThe solid material precipitated
  2. temperatureafter cooling
  3. filtrationis filtered of with suction
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8cd74c40b3eb45159312de40f7833fbe
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04667033

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