HCID 14654393, Verbindung → cis-Azetidine-2,4-dicarboxylic acid
Reaktionsgleichung
C([O:8][C:9]([C@H:11]1[CH2:14][C@@H:13]([C:15]([O:17]CC2C=CC=CC=2)=[O:16])[N:12]1CC1C=CC=CC=1)=[O:10])C1C=CC=CC=1>CO.O.[Pd]>[NH:12]1[C@H:13]([C:15]([OH:17])=[O:16])[CH2:14][C@@H:11]1[C:9]([OH:10])=[O:8]Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
208 mg (0.5 mmol) of stereochemically pure transor cis-N-benzylazetidine-2,4-dicarboxylic acid dibenzyl ester and 20 mg of 10% Pd/C in 15 ml of methanol are hydrogenated as above. The reaction mixture is diluted with 50 ml of warm water, filtered, and evaporated to dryness to afford as off-white solids the trans- or cis azetidine-2,4-dicarboxylic acid in virtually quantitative yield.
Aufarbeitung
- filtrationfiltered
- customevaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-64472fa02f594f64b05a762d3fbb4a40
- Quelldatensatz
- uspto-grants-1991_02
- Patentnummer
- US04990504
Notizen zur Reaktion
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