1,6-Dibromohexane → 5-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

HRID 982384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 982384
[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1.[OH-].[Na+].[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]Br>O.CCOCC>[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]1[CH:6]=[N:1][CH:2]=[N:3][CH:4]=1

Komponenten

6

Edukt 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 135575446-(Pyrimidin-5-yl)hexan-1-ol

Produkt 1

HCID 198767545-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 5-pyrimidinehexanol (1.82 g), 50% sodium hydroxide (6 ml), 1,6-dibromohexane (6 ml) and TAB (150 mg) was vigorously stirred at room temperature for 30 h then diluted with water (20 ml) and ether (25 ml). The organic phase was dried and evaporated in vacuo. The residue was purified by FCC eluting with hexane followed by hexane-ether (1:1) and ether, to give the title compound as a colourless liquid (2.21 g), t.l.c. (ether) Rf 0.35.

Aufarbeitung

  1. customThe organic phase was dried
  2. customevaporated in vacuo
  3. customThe residue was purified by FCC
  4. washeluting with hexane

Quellen und Nachweise

ORD-Eintrag
ord-385cdbf4a8c340ed90403123ae3429cc
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04996218

Notizen zur Reaktion

Wird geladen…