Formic Acid → N-formyl-2-(benzyloxyaminomethyl)-4-methylpentanoic acid
Reaktionsgleichung
[CH2:1]([O:8][NH:9][CH2:10][CH:11]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:19](O)=[O:20]>C(OC(=O)C)(=O)C>[CH:19]([N:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:10][CH:11]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([OH:14])=[O:13])=[O:20]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1.0 g of N-benzyloxy 2(RS)-isobutyl-3-amino-propionic acid in 10 ml of formic acid and 1 ml of acetic anhydride was stirred at room temperature for 2 hours and then evaporated. The residue was taken up in ethyl acetate, washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to yield 1.2 g (100%) of N-formyl-N-benzyloxy 2(RS)-isobutyl-3-aminopropionic acid as a gum. Rf (toluene/acetic acid 4:1) 0.39.