Water → HCID 10460715, Verbindung

HRID 982715Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 982715
C(N(C(C)C)CC)(C)C.[Cl:10][C:11]1[CH:39]=[CH:38][C:14]([CH2:15][NH:16][C:17]([C:19]2[C:20](=[O:37])[C:21]3[S:34][C:33]([CH2:35]Cl)=[CH:32][C:22]=3[N:23]([CH2:25][C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27])[CH:24]=2)=[O:18])=[CH:13][CH:12]=1.[O:40]1[CH:44]=[CH:43][CH:42]=[C:41]1[CH:45]([OH:49])[CH2:46][NH:47][CH3:48].O>CN(C=O)C>[Cl:10][C:11]1[CH:39]=[CH:38][C:14]([CH2:15][NH:16][C:17]([C:19]2[C:20](=[O:37])[C:21]3[S:34][C:33]([CH2:35][N:47]([CH2:46][CH:45]([C:41]4[O:40][CH:44]=[CH:43][CH:42]=4)[OH:49])[CH3:48])=[CH:32][C:22]=3[N:23]([CH2:25][C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27])[CH:24]=2)=[O:18])=[CH:13][CH:12]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 11320981Rac-1-(2-furyl)-2-(methylamino)ethanolHCID 22563219HCID 22563219, Verbindung

Produkt 1

HCID 10460715HCID 10460715, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Diisopropylethylamine (34 μL, 0.19 mmol) was added to a mixture of N-(4-chlorobenzyl)-2-(chloromethyl)-4-{2-[methoxy(methyl)amino]-2-oxoethyl}-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide (60 mg, 0.13 mmol) and 1-(2-furyl)-2-(methylamino)ethanol (27 mg, 0.19 mmol) in DMF (2.0 mL). The mixture was shaken at 60° C. for 3 hrs. The reaction was cooled to room temperature before the addition of water (5 mL). The resulting ppt was collected by filtration and washed with water. After drying in vacuo, the title compound was obtained as a pale yellow solid (41 mg).

Aufarbeitung

  1. filtrationThe resulting ppt was collected by filtration
  2. washwashed with water
  3. customAfter drying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bdd54befa5c6498b8ef0af1f15061c0f
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06861438B2

Notizen zur Reaktion

Wird geladen…