Hydrochloric Acid → Biphenyl phenyl-carbinol

HRID 985131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 985131
[C:1]1([C:7]2[CH:20]=[CH:19][C:10]([C:11](C3C=CC=CC=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].O.Cl>C(O)C>[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[CH:19][CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]1([CH2:11][OH:12])[CH:19]=[CH:20][CH:7]=[CH:8][CH:9]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 750404-Benzoylbiphenyl3×HCID 4311764Sodium borohydride

Produkt 1

HCID 21946058Biphenyl phenyl-carbinol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The method of synthesis presented in Ger.Pat. 2,461,406 uses 4-phenylbenzophenone as partition reactant, and has 2 or three steps, depending on the variation of synthesis to use. One of the variations comprises the dissolution of 4-phenylbenzophenone in ethanol, then adding sodium borohydride in a 1:2 molar relation to 4-phenyl benzophenone, for the reduction of ketone to alcohol. The system is heated to reflux during fifteen hours, it is let to cool down and the reaction mixture is hydrolyzed with water acidulated with HCl, the solid obtained is purified by recrystallization in ethanol. 89% of the theoretical yield of biphenyl-phenyl-carbinol is obtained.

Aufarbeitung

  1. customThe method of synthesis
  2. customas partition reactant
  3. customdepending on the variation of synthesis
  4. temperatureThe system is heated
  5. temperatureto reflux during fifteen hours
  6. temperatureto cool down
  7. customthe solid obtained
  8. customis purified by recrystallization in ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3ada3ac8b0e14d989db98a999ea5f2bc
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06870057B1

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