Sodium Dithionite → HCID 22506839, Verbindung

HRID 985572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 985572
[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4]([C:5]([CH3:13])=[CH:6][C:7](=[O:12])[C:8]=2[CH3:11])=[N:3]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(OCC)(=O)C.O>[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4](=[C:5]([CH3:13])[CH:6]=[C:7]([OH:12])[C:8]=2[CH3:11])[NH:3]1

Komponenten

5

Edukt 2

HCID 24489Sodium DithioniteHCID 22506843HCID 22506843, Verbindung

Produkt 1

HCID 22506839HCID 22506839, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2,3-dihydro-2,2,4,7-tetramethyl-5H-indol-5-one (7.36 g, 38.9 mmol) in ethyl acetate (100 ml) was added a solution of sodium hydrosulfite (14.9 g, 85.6 mmol) in water (50 ml) and shaken. The aqueous layer was separated, and the organic layer was washed with water and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from ethanol-hexane to obtain 6.17 g of the title compound.

Aufarbeitung

  1. customThe aqueous layer was separated
  2. washthe organic layer was washed with water and saturated brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from ethanol-hexane

Quellen und Nachweise

ORD-Eintrag
ord-a3b42db1da98424989d852b792cf547c
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06872718B1

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