Methyl Ethyl Ketone → 2-(3,5-Dimethylbenzyl)-butan-2-ol

HRID 985905

Reaktionsgleichung

Reaktionsgleichung von HRID 985905
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:5][Mg]Cl.[Mg].CC1C=C(C=C(C)C=1)CCl.[CH2:23]([C:25]([CH3:27])=[O:26])[CH3:24]>C(OCC)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:5][C:25]([OH:26])([CH2:23][CH3:24])[CH3:27]

Komponenten

6

Edukt 4

HCID 6569Methyl Ethyl KetoneHCID 1377003,5-Dimethylbenzyl chlorideHCID 5462224MagnesiumHCID 178424989HCID 178424989, Verbindung

Produkt 1

HCID 201586592-(3,5-Dimethylbenzyl)-butan-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

3,5-dimethylbenzylmagnesium chloride was manufactured from 2.6 g of magnesium powder and 15.5 g of 3,5-dimethylbenzyl chloride dissolved in 200 ml of diethyl ether and reacted with 7.5 g of methyl ethyl ketone in a temperature range of from 20° C. to 25° C. After 2 hours, the whole was poured onto ice and acidified, and the organic phase was separated off and extracted by shaking with water and sodium bicarbonate solution. After drying the organic phase with solid potassium carbonate, fractional distillation was carried out. 13 g of end product were obtained in a temperature range of from 63° C. to 65° C. at 0.12 mbar.

Aufarbeitung

  1. additionthe whole was poured onto ice
  2. customthe organic phase was separated off
  3. extractionextracted
  4. customAfter drying the organic phase
  5. distillationwith solid potassium carbonate, fractional distillation
  6. custom13 g of end product were obtained in a temperature range of from 63° C. to 65° C. at 0.12 mbar

Quellen und Nachweise

ORD-Eintrag
ord-c5cf898648e64a9ba7ebd5dade721ba4
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04710316

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