Diclofenac sodium → Diclofenac

HRID 990889Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 990889
C(O)(=O)CCCCCCCCCCC/C=C\CCCCCCCC.[CH:25]1[CH:30]=[C:29]([CH2:31][C:32]([O-:34])=[O:33])[C:28]([NH:35][C:36]2[C:41]([Cl:42])=[CH:40][CH:39]=[CH:38][C:37]=2[Cl:43])=[CH:27][CH:26]=1.[Na+]>C(O)C>[CH:25]1[CH:26]=[CH:27][C:28]([NH:35][C:36]2[C:41]([Cl:42])=[CH:40][CH:39]=[CH:38][C:37]=2[Cl:43])=[C:29]([CH2:31][C:32]([OH:34])=[O:33])[CH:30]=1

Komponenten

4

Edukt 2

HCID 5018304Diclofenac sodiumHCID 5281116Erucic Acid2×

Produkt 1

HCID 3033Diclofenac

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A rectal suppository comprising erucic acid, beeswax, and the medicine diclofenac was prepared as follows: About 8.08 kg of micronized sodium diclofenac was added to a homogenous melt containing about 122.34 kg of erucic acid and about 13.57 kg of beeswax at a temperature of about 75° C. The medicine and suppository base was mixed gently until homogenous and the ethanol evaporated then poured into a mold. Upon cooling the suppository was removed from the mold.

Aufarbeitung

  1. customevaporated
  2. additionthen poured into a mold
  3. temperatureUpon cooling the suppository
  4. customwas removed from the mold

Quellen und Nachweise

ORD-Eintrag
ord-481f1ea819d34825855d9335b98da7be
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06462083B1

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