Hydrochloric Acid → MLS002695130

HRID 993059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 993059
[CH:1](=[C:8]1[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O.Cl>CO>[CH2:1]([CH:8]1[C:9](=[O:16])[NH:10][C:11](=[O:15])[NH:12][C:13]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2411295-Benzylidenebarbituric acidHCID 4311764Sodium borohydride

Produkt 1

HCID 260790MLS002695130

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 5-benzylidenebarbituric Acid (4 g) in 200 ml of methanol are added portionwise 1.4 g of sodium borohydride. After 10 minutes from the end of the addition, 100 ml of water are added and the mixture is acidified with 1 N hydrochloric acid to pH=2. The solvent is evaporated off and the aqueous phase is extracted with ethyl acetate. The pooled extracts are dried over sodium sulfate and concentrated to dryness. 3.6 g of the product crystallize, m.p. 207-209° C.

Aufarbeitung

  1. additionare added
  2. customThe solvent is evaporated off
  3. extractionthe aqueous phase is extracted with ethyl acetate
  4. dry with materialThe pooled extracts are dried over sodium sulfate
  5. concentrationconcentrated to dryness
  6. custom3.6 g of the product crystallize

Quellen und Nachweise

ORD-Eintrag
ord-8fe768fe0fed4a3999ca21754de35712
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06472396B1

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