Basic information
- Standard SMILES
NO.O=[N+]([O-])O- InChIKey
NILJXUMQIIUAFY-UHFFFAOYSA-N- Molecular formula
- H4N2O4
- Average molar mass
- 96.04 g/mol
- Monoisotopic mass
- 96.01710661
Overview
Hydroxylammonium nitrate (HAN) is the salt of hydroxylamine and nitric acid. It is being developed as a potential rocket propellant and is sometimes used in nuclear reprocessing as a plutonium reductant. Nitrite is a toxic compound known to cause methemoglobinemia. (L1137, L1628)
Names & identifiers
- Preferred name
- Hydroxylammonium nitrate
- IUPAC
- hydroxylamine;nitric acid
- English name
- Hydroxylamine nitrate
- Molecular formula
- H4N2O4
- Molecular weight
- 96.04
Names & synonyms
DTXSID30884613hydroxyazanium nitrateRefChem:1087090DTXCID501024044236-691-213465-08-2Hydroxylammonium nitrateHYDROXYLAMINE NITRATESCHEMBL148735SCHEMBL2359610SCHEMBL9695641SCHEMBL13560600
Show more names
HANhydroxyazanium,nitrateHYDROXYLAMMONIUM OXALATEhydroxylamine,nitrate(salt)Hydroxylamine nitrate solutionHydroxylamine solution nitrateHydroxylammonium nitrate solutionHYDROXYLAMINENITRATE,AQUEOUSSOLUTION
Nitric acid--hydroxylamine (1/1)
Database identifiers
- CAS
13465-08-2- PubChem CID
- 10129901
- DTXSID
DTXSID30884613- EC Number
- 236-691-2
Properties
Computed structural properties
- Topological polar surface area
- 112 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 0
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 26.8
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Explosives
Density1.156 @25 °C
Physical DescriptionAqueous solution; [Sigma-Aldrich MSDS]
Physicochemical properties
- Density
- 1.09 g/mL · 1.09 g/mL at 20 °C
- vapor pressure
- 9.33 hPa · 9.33hPa at 25℃
- Viscosity
- 0.896 mm2/s · 0.896mm2/s
- Water Solubility
- 587 g/L · 587g/L at 20℃
- LogP
- -3.6 · -3.6
- CAS DataBase Reference
- 13465 · 13465-08-2
- EPA Substance Registry System
- Hydroxylamine nitrate (13465-08-2)
- Symbol(GHS)
- 1 · GHS01,GHS06,GHS08,GHS09
- Signal word
- Danger
- Hazard statements
- 201 · H201-H302-H311-H315-H319-H317-H351-H373-H400
- Precautionary statements
- 210 · P210-P230-P234-P240-P250-P280-P264-P270-P261-P272-P201-P202-P260-P273-P301+P312-P330-P302+P352-P312-P361+P364-P332+P313-P362+P364-P305+P351+P338-P337+P313-P333+P313-P308+P313-P314-P391-P401-P405-P501
- Hazard Codes
- Xn,C,Xi,N
- Risk Statements
- 1 · 1-22-36/37/38-43-48/22-34-20/21/22-50
- Safety Statements
- 26 · 26-36/37-45-36/37/39-35-61
- RIDADR
- 1759 · 1759
- WGK Germany
- 3 · 3
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- III
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Danger
H201: (Deleted) Explosive; mass explosion hazard [Danger Explosives]
P203, P210, P230, P240, P250, P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P380, P372, P373, P391, P401, P405, and P501 (click each P-code to see the statement)
Danger
H201 (100%): (Deleted) Explosive; mass explosion hazard [Danger Explosives]
P203, P210, P230, P240, P250, P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P380, P372, P373, P391, P401, P405, and P501 (click each P-code to see the statement)
Hazard information
Regulatory InformationStatus: Active Update: 29-04-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/6670
Hazards Summary
Classifications by the EC: Risk of explosion by shock, friction, fire, or other sources of ignition; Limited evidence of a carcinogenic effect; Toxic in contact with skin; Harmful by ingestion (danger of serious damage to health by prolonged exposure); Irritating to skin and eyes; May cause sensitization by skin contact; [EC: SCCS] A skin and strong eye irritant; May cause CNS depression, respiratory sensitization, and induce methemoglobinemia; Harmful by ingestion; Highly toxic by skin absorption; [Sigma-Aldrich MSDS] See Hydroxylamine. See NITRATES and NITRITES.
Hazard Classes and Categories
Expl. 1.1 (100%)
Explosive - division 1.1
Expl. 1.1 ****
Safety & protection
Protective Action Criteria (PAC)
0.16 [ppm]
24 [ppm]
92 [ppm]
Toxicology
Treatment
Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)
Health EffectsNitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)
Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Exposure RoutesOral (L1137) ; inhalation (L1137)
Toxicity Summary
Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)
Signs and Symptoms
Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)
Carcinogen ClassificationIngested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)
Safety data
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- 1759
- risk_code
- 1-22-36/37/38-43-48/22-34-20/21/22-50
- Signal word
- Danger
- Symbol(GHS)
- GHS01,GHS06,GHS08,GHS09
- hazard_code
- Xn,C,Xi,N
- safety_code
- 26-36/37-45-36/37/39-35-61
- hazard_class
- 8
- packing_group
- III
- Hazard statements
- H201-H302-H311-H315-H319-H317-H351-H373-H400
- REACH Registrations
- Active
- Precautionary statements
- P210-P230-P234-P240-P250-P280-P264-P270-P261-P272-P201-P202-P260-P273-P301+P312-P330-P302+P352-P312-P361+P364-P332+P313-P362+P364-P305+P351+P338-P337+P313-P333+P313-P308+P313-P314-P391-P401-P405-P501
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137)
Suppliers4 total
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Related reactions
2 records
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