Magnesium Stearate → Clonidine

HRID 716609

Reaction equation

HRID 716609 reaction equation
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([NH:8][C:9]2[NH:13][CH2:12][CH2:11][N:10]=2)=[C:3]([Cl:14])[CH:2]=1.Cl.OP([O-])([O-])=O.[Ca+2].C([O-])(=O)CCCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=O)CCCCCCCCCCCCCCCCC>>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([NH:8][C:9]2[NH:13][CH2:12][CH2:11][N:10]=2)=[C:3]([Cl:14])[CH:2]=1

Participants

4

Reactant 3

HCID 11177Magnesium StearateHCID 20179Clonidine HydrochlorideHCID 24441Calcium hydrogen phosphate

Product 1

HCID 2803Clonidine

Procedure

Basically 0.1 mg (base equivalent) of clonidine hydrochloride was blended with 13 mg of calcium phosphate dibasic, with 15 mg of microcrystalline cellulose, with 40 mg of hydroxypropyl methyl cellulose, 1 mg of colloidal silica and 0.9 mg of magnesium stearate.

Sources & evidence

ORD record
ord-3dcf1e25c5e44415a5fca05c8929c813
Source dataset
uspto-grants-2015_11
Patent number
US09192599B2

Linked notes

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