5-Amino-2-methylpyridine

HCID 243313CAS 3430-14-6
Substructure searchFind similar structures

Basic information

Standard SMILES
Cc1ccc(N)cn1
InChIKey
UENBBJXGCWILBM-UHFFFAOYSA-N
Molecular formula
C6H8N2
Average molar mass
108.14 g/mol
Monoisotopic mass
108.06874826

Names & identifiers

Preferred name
5-Amino-2-methylpyridine
IUPAC
6-methylpyridin-3-amine
English name
5-Amino-2-methylpyridine
Molecular formula
C6H8N2
Molecular weight
108.14

Names & synonyms

5-Amino-2-methylpyridine6-methylpyridin-3-amine3430-14-6DTXSID00287854RefChem:532218DTXCID10239001625-232-53-Amino-6-methylpyridine5-Amino-2-picoline3-Amino-6-picoline6-methyl-3-pyridinamine80287-53-2
Show more names
6-METHYL-PYRIDIN-3-YLAMINEAURORA KA-79235-Aminopicoline5-Amino-2-methylpyri6-Methyl-Pyridin-3-yl5-Amino-2-methypyridine
MFCD008333896-methylpyridine-3-amine5-amino-2-methylpyridin3-amino-6-methyl-pyridineNSC 52872PB32227PS-9287EN300-42380

Database identifiers

CAS
3430-14-6
PubChem CID
243313
DTXSID
DTXSID00287854
EC Number
625-232-5
Nikkaji
J83.254E

Properties

Computed structural properties

XLogP
0.5
Topological polar surface area
38.9 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
8

Physicochemical properties

Melting point
95 · 95-99°C
Boiling point
238.4 · 238.4±20.0 °C(Predicted)
Density
1.068 · 1.068±0.06 g/cm3(Predicted)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
pka
6.89 · 6.89±0.10(Predicted)
form
Powder

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H301 (12.5%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationStatus: Active Update: 07-06-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/29319
Hazard Classes and CategoriesAcute Tox. 3 (12.5%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
wgk
3
ridadr
UN2811
hs_code
29333999
risk_code
22-37/38-41-36/37/38-34-24/25
Signal word
Danger

Chemistry & industry

Applications · 2 items

Uses6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.

General Description5-Amino-2-methylpyridine is used as a pharmaceutical intermediate for Omecamtiv Mecarbil, a selective cardiac myosin activator used to improve cardiac function.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海泰矶林实业有限公司02150630626 17717886015 · [email protected]

Related reactions

46 records
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Linked notes

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