Reaction equation
CO[C:3](=[O:20])[C:4]([C:9](=[O:19])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([F:18])[CH:11]=1)=[CH:5]OCC.[CH3:21][C:22]1[N:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[F:18][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][C:13]=1[O:16][CH3:17])[C:9]([C:4]1[C:3](=[O:20])[C:26]2[C:25](=[CH:24][CH:23]=[C:22]([CH3:21])[N:27]=2)[NH:28][CH:5]=1)=[O:19]Participants
4
Procedure
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (1.86 mmol) of 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl) acrylic acid methyl ester, 0.20 g (1.86 mmol) of 6-Methyl-pyridin-3-ylamine, and 15 mL of diphenyl ether to yield 0.233 g of 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
Sources & evidence
- ORD record
- ord-7f3268ff5099482da893501dce9868c8
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07557213B2
Linked notes
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