Calcium hypochlorite

HCID 24504CAS 7778-54-3

Basic information

Standard SMILES
[Ca+2].[O-]Cl.[O-]Cl
InChIKey
ZKQDCIXGCQPQNV-UHFFFAOYSA-N
Molecular formula
Ca(ClO)2
Average molar mass
142.98 g/mol
Monoisotopic mass
141.89012558

Overview

Obtained by saturating calcium hydroxide (slaked lime) with chlorine.

Names & identifiers

Preferred name
Calcium hypochlorite
IUPAC
calcium dihypochlorite

Names & synonyms

CALCIUM HYPOCHLORITE7778-54-3Calcium hypochlorideHypochlorous acid, calcium saltBleaching powderPittchlorPittcidePittclorChemichlor GChlorine of limeSolvox KST-Eusol
Show more names
Chlorolime chemicalHTH (bleaching agent)Calcium chlorohypochlorideHipoclorito calcicoCalcium chlorohydrochloriteHypochlorite de calciumEPA Pesticide Chemical Code 014701UN 1748

Database identifiers

CAS
7778-54-3
PubChem CID
24504
DTXSID
DTXSID1029700
ChEMBL
CHEMBL2251447
ChEBI
CHEBI:31342
UNII
11DXB629VZ
EC Number
231-908-7

Properties

Computed structural properties

Topological polar surface area
46.1 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
5

Experimental & physicochemical properties

Chemical Classes · 2 items

Other Classes -> Inorganic Oxidizing Agents

Reactive agents - 1st degree

OdorStrong chlorine odor
Density · 3 items

2.350 g/cu cm

2.35 g/cm³

2.35 @25 °C

Color/Form · 3 items

Powder

WHITE GRANULES OR PELLETS

White crystalline solid

Solubility · 2 items

21% in water at 25 °C

Solubility in water, g/100ml at 25 °C: 21

Corrosivity0.001 mm ASTM grade 2 titanium/yr at 6 wt% and 100 °C /From table/

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P260, P264, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P391, P405, and P501 (click each P-code to see the statement)

Danger

H271 (12%): May cause fire or explosion; strong Oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P260, P264, P270, P273, P280, P283, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P321, P330, P363, P370+P378, P371+P380+P375, P391, P405, P420, and P501 (click each P-code to see the statement)

Hazard information

Regulatory Information · 5 items

Chemical: Hypochlorous acid, calcium salt

Hypochlorous acid, calcium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hypochlorous acid, calcium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: No longer Valid Update: 15-08-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/1611

Calcium hypochlorite, hydrated, with not less than 5.5% but not more than 16% water: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationIMAP assessments - Hypochlorous acid, calcium salt: Human health tier II assessment
DOT Label · 2 items

Oxidizer

Oxidizer

Fire Hazards · 6 items

Excerpt from ERG Guide 140 [Oxidizers]:

Excerpt from ERG Guide 140 [Oxidizers]:

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

Fire Potential · 6 items

Contact with combustible materials will increase fire hazard. May undergo accelerated decomposition with release of heat above 350 °F (177 °C). /Calcium hypochlorite, dry, or calcium hypochlorite, mixtures, dry/

Contact of solid hypochlorite with glycerol, digol monomethyl ether, or phenol causes ignition within few minutes, accompanied by irritant smoke, particularly with phenol (formation of chlorophenols).

Contents of a drum /of calcium hypochlorite/ erupted & ignited during intermittent use. This was attributed to contamination of soldered metal scoop (normally kept in the drum) by oil, grease or water, or all three, & subsequent exothermic reaction with the ... /hypochlorite/.

... The hypochlorite constitutes a hazard in the absence of other combustible materials, because after initiation, local rapid thermal decomp will spread through the contained mass of hypochlorite as a vigorous fire which evolves, rather than consumes, oxygen.

May cause fire in contact with wood or straw.

Not flammable /SRP: Acts as oxidizer with combustible material./

Health Hazards · 6 items

Excerpt from ERG Guide 140 [Oxidizers]:

Excerpt from ERG Guide 140 [Oxidizers]:

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

Safety & protection

Fire Fighting · 3 items

Excerpt from ERG Guide 140 [Oxidizers]:

Excerpt from ERG Guide 140 [Oxidizers]:

NO powder. Use water in large amounts. In case of fire: keep drums, etc., cool by spraying with water.

First Aid Measures · 4 items

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

Accidental Release Measures · 6 items

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

First Aid · 6 items

Excerpt from ERG Guide 140 [Oxidizers]:

Excerpt from ERG Guide 140 [Oxidizers]:

General First Aid:

General First Aid:

General First Aid:

General First Aid:

Safe StorageWell closed. Store in an area without drain or sewer access. Separated from food and feedstuffs. See Chemical Dangers.
Firefighting HazardsSince a calcium hypochlorite fire will generate its own oxygen, attempts to smother it will not be effective, and it must be quenched with water.

Toxicology

Ecotoxicity Values · 5 items

LC50; Species: Colinus virginianus (Northern bobwhite quail) age 9 days; diet >5620 ppm for 8 days

LC50; Species: Anas platyrhynchos (Mallard duck) age 10 days; diet >5620 ppm for 8 days

LD50; Species: Anas platyrhynchos (Mallard duck) age 25 weeks; oral via capsule >105 mg/kg

LD50; Species: Colinus virginianus (Northern bobwhite quail) age 27 weeks; oral via capsule; oral via capsule 1502 mg/kg (95% confidence interval: 1097-2561 mg/kg)

For more Ecotoxicity Values (Complete) data for CALCIUM HYPOCHLORITE (64 total), please visit the HSDB record page.

Adverse EffectsDermatotoxin - Skin burns.
Exposure RoutesThe substance can be absorbed into the body by ingestion and by inhalation.
Ecotoxicity Excerpts · 1 item

/AQUATIC SPECIES/ The aquatic effect of calcium hypochlorite in the environment, where pH value is supposed to range from 6 to 8, is common to other hypochlorite-generating chemicals like chlorine gas or sodium hypochlorite. The biologically significant chemical species are hypochloric acid or hypochlorite ion. /Hypochlorite/

Signs and Symptoms · 4 items

Burning sensation. Sore throat. Wheezing. Laboured breathing. Shortness of breath.

Redness. Pain. Serious skin burns. Blisters.

Redness. Pain. Blurred vision. Severe deep burns.

Abdominal pain. Burning sensation. Shock or collapse.

Acute Toxicity LinkChemical: CALCIUM HYPOCHLORITE

Regulatory information

FIFRA Requirements · 5 items

Residues of the following materials are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Inert Ingredient: calcium hypochlorite; Use: sanitizing and bleaching agent.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Hypchlorous acid, calciuim salt is included on this list. Limit: When ready for use, the end-use concentration of all hypochlorous acid chemicals in the solution is not to exceed 200 ppm determined as total available chlorine.

Calcium hypochlorite is exempted from the requirement of a tolerance when used preharvest or postharvest in solution on all raw agricultural commodities. Calcium hypochlorite is exempted from the requirement of a tolerance in or on grape when used as a fumigant postharvest by means of a chlorine generator pad.

Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic (i.e., active ingredient specific) data required to support reregistration of products containing ... calcium hypochlorite as a active ingredient. The Agency has completed its review of these generic data, and has determined that the data are sufficient to support reregistration of products containing ... calcium hypochlorite.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Calcium hypochlorite is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0029; Pesticide type: fungicide, antimicrobial (bactericide); Registration Standard Date: 02/01/86; Case Status: RED Approved 09/91; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): calcium hypochlorite; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.

CERCLA Reportable Quantities · 1 item

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Clean Water Act Requirements · 1 item

Calcium hypochlorite is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Chemistry & industry

Pharmacology

Bionecessity · 1 item

Hypochlorous ions are physiologically present in the human body, being formed by white blood cells (neutrophils and monocytes) as a powerful antimicrobial agent during inflammation process. When the recognition of "non-self" proteins in an invading micro-organism triggers the immune response, the enzyme myeloperoxidase located in mammalian neutrophils catalyses hypochlorous acid formation trough the oxidation of chloride ion in combination with hydrogen peroxide. The endogenously formed hypochlorous acid plays a key role in the process of phagocytosis through which bacteria are killed. Due to its potent cytotoxic action, hypochlorite is also responsible for neutrophil-mediated tissue damage associated with the inflammatory response. Its high efficiency as antimicrobial agent is associated with the lack of a catalytically active detoxifying mechanism for HOCl in both bacteria and mammalian cells. Although it has been suggested that HOCl-induced cytotoxicity can be associated to the degradation of a number of functionally important molecules the primary mechanism of action is still not fully elucidated. /Hypochlorite/

Mechanism of Action · 1 item

Hypochlorous ions are physiologically present in the human body, being formed by white blood cells (neutrophils and monocytes) as a powerful antimicrobial agent during inflammation process. When the recognition of "non-self" proteins in an invading micro-organism triggers the immune response, the enzyme myeloperoxidase located in mammalian neutrophils catalyses hypochlorous acid formation trough the oxidation of chloride ion in combination with hydrogen peroxide. The endogenously formed hypochlorous acid plays a key role in the process of phagocytosis through which bacteria are killed. Due to its potent cytotoxic action, hypochlorite is also responsible for neutrophil-mediated tissue damage associated with the inflammatory response. Its high efficiency as antimicrobial agent is associated with the lack of a catalytically active detoxifying mechanism for HOCl in both bacteria and mammalian cells. Although it has been suggested that HOCl-induced cytotoxicity can be associated to the degradation of a number of functionally important molecules the primary mechanism of action is still not fully elucidated. /Hypochlorite/

Metabolism/Metabolites · 1 item

It is well known from studies on HClO in inflammation processes that HClO is not enzymatically metabolised and its (bio)transformation readily occurs through direct reactions with organic compounds or with other chemicals present in the cellular environment, including hydrogen peroxide. The toxicokinetic study showed that chloride ion accounted for >80% (36)Cl radioactivity present in rat plasma. /Hypochlorite/

Absorption, Distribution and Excretion · 2 items

Only ca. 50% is excreted mainly with the urine followed by excretion with feces. /Sodium hypochlorite/

Most of the data for toxicity of this substance by the oral route came from studies performed with sodium hypochlorite or chlorine gas. In biological systems, characterized by pH values in the range of 6-8, the most abundant active chemical species is HClO, in equilibrium with ClO-. Such available chlorine is readily absorbed via the oral route and distributed into plasma, bone marrow, testis, skin, kidney and lung. /sodium hypochlorite/

Uses & manufacturing

Uses · 6 items

Used for swimming pool sanitation and other water treatment; Used in industries to disinfect, to control mildew, and to bleach textiles and paper; [CHEMINFO]

Pulp and Paper Processing [Category: Industry]

Disinfectant for drinking water and swimming pools; algicide; oxidizing agent; as household and industrial bleaching agent and sanitizer

Potable-water purification, bleaching agent (paper, textiles)

Calcium hypochlorite is used to cleanup hydrazine spills. Recommended procedure is discussed.

Chlorinated lime ... 2% strength ... used on grossly contaminated premises. Boric acid ... often used with it. Chlorinated lime/

Impurities · 3 items

Commercial products normally contain various impurities such as CaCl2, CaCO3, Ca(OH)2 and water.

MgO, CaCO3, CaSO4, Al2O3, FeO3, and trace metals such as cobalt, nickel, copper and manganese.

Bromate was first reported as a disinfection by-product from ozonated waters, but more recently it has been reported also as a result of treatment using hypochlorite solutions worldwide. The aim of this study was to study the scope of this phenomenon in the drinking waters (n=509) of Castilla and Leon, Spain, and in the hypochlorite disinfectant reagents. Two thirds of the treated waters monitored were found to have bromate concentrations higher than 1 ug/L, and of them a median value of 8 ug/L and a maximum of 49 ug/L. These concentrations are higher than those reported so far, however, a great variability can be found. Median values for chlorite were of 5 ug/L, and of 119 ug/L for chlorate. Only 7 out of 40 hypochlorite feedstock solutions were negative for bromate, the rest showing a median of 1022 mg/L; and 4 out of 14 calcium hypochlorite pellets were also negative, the rest with a median of 240 mg/kg. Although bromate is cited as potentially added to water from calcium hypochlorite pellets, no reference is found in scientific literature regarding its real content. Chlorite (median 2646 mg/L) and chlorate (median 20,462 mg/L) and chlorite (median 695 mg/kg) and chlorate (median 9516 mg/kg) were also monitored, respectively, in sodium hypochlorite solutions and calcium hypochlorite pellets. The levels of chlorite and chlorate in water are considered satisfactory, but not those of bromate, undoubtedly owing to the high content of bromide in the raw brines employed by the chlor-alkali manufacturers. Depending on the manufacturer, the bromate concentrations in the treated waters may be very heterogeneous owing to the lack of specification for this contaminant in the disinfectant reagents -the European Norms EN 900 and 901 do not mention it.

U.S. Exports · 3 items

(1984) 1.11X10+9 g

(1987) 4,382,677 lb

(1987) 512,096 lb /Calcium lime, chlorinated no more than 40% chlorine/

U.S. Imports · 5 items

(1972) 9.07X10+8 G

(1975) 1.25X10+9 G

(1984) 4.02X10+9 g

(1986) 14,067,471 lb

(1986) 1,270,989 lb /Lime chlorinated with not more than 40% available chlorine/

U.S. Production · 6 items

2023: 1,000,000 - <8,500,000 lb

(1972) 4.8X10+10 G

(1975) 6.36X10+10 G (DEMAND)

(1984) 5.04X10+9 g /est-based on export value equal to 22% of production/

Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#2416]

For more U.S. Production (Complete) data for CALCIUM HYPOCHLORITE (6 total), please visit the HSDB record page.

Consumption Patterns · 5 items

Swimming pool sanitation and other bleaching and sanitation (municipal and industrial) uses, 78%; Exports, 22% (1986)

CHEMICAL PROFILE: Calcium hypochlorite. Residential swimming pool sanitation, 65%; municipal and industrial bleaching and sanitation, 15%; exports, 20%.

CHEMICAL PROFILE: Calcium hypochlorite. Demand: 1988: 120,000 tons; 1989: 122,000; 1993 /projected/: 132,000 tons. (Includes exports, but not imports, which totaled 6,000 tons last year.)

Residential swimming pool sanitation 75%, municipal and industrial bleaching and sanitation 25%.

For more Consumption Patterns (Complete) data for CALCIUM HYPOCHLORITE (6 total), please visit the HSDB record page.

Related reactions

32 records

Linked notes

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