N-Nitrosodiphenylamine

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use foam, powder, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Decontamination of N-nitrosamine contaminated glassware /was described/. /N-nitrosamines/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.

Incineration: Pour or sift onto a thick layer of sand and soda ash mixture (90-10). Mix and shovel into a heavy paper box with much paper packing. Burn in an incinerator. Fire may be augmented by adding excelsior and scrap wood. Waste may be dissolved in flammable solvent (alcohols, etc) and sprayed into fire box of an incinerator with afterburner and scrubber.

(1) Nitrosamines may be reduced to the corresponding amine by using nickel-aluminum (Ni-Al) alloy in dilute base. The nitrosamines were completely degraded (99.9%) and only the amines (RR'NH) were found in the final reaction mixtures. No traces (generally <0.1%) of the corresponding, possibly carcinogenic, hydrazines (RR'NNH2) were found in the final reaction mixtures. (2) Nitrosamines may be oxidized by potassium permanganate in 3 M sulfuric acid (KMnO4 in H2SO4). The nitrosamines were completely destroyed (>99.5%). The products of this reaction have not been determined. (3) Nitrosamines may be destroyed by using hydrogen bromide (HBr) in glacial acetic acid. The nitrosamines were completely destroyed (>99%) and the products were presumably the corresponding amines. All of these procedures were validated by an international collaborative study. /Nitrosamines/

For more Disposal Methods (Complete) data for N-Nitrosodiphenylamine (9 total), please visit the HSDB record page.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For more Preventive Measures (Complete) data for N-Nitrosodiphenylamine (14 total), please visit the HSDB record page.

ATSDR Toxicological Profile for n-Nitrosodiphenylamine - Succinctly characterizes the toxicologic and adverse health effects information.

Ranking: 123 (total points: 1075.8599999999999)

The mutagenicity of the carcinogen N-nitrosodiphenylamine (NDPhA) to Salmonella typhimurium TA98 was demonstrated only when norharman, a comutagen, was added to the incubation mixture with S9 mix. N,N-Diphenylamine (DPhA), a denitrosated derivative of NDPhA, was also mutagenic to S. typhimurium TA98 when norharman was present. Twice as many revertants were induced by DPhA with norharman as by NDPhA with norharman. The comutagenic effect of norharman was also observed with N-nitroso-methylphenylamine (NMPhA), N-nitrosoethylphenylamine (NEPhA) and N-nitrosophenylbenzylamine (NPhBeA) and their denitrosated derivatives. NDPhA was converted metabolically to DPhA by S9 mix. Stoichiometric studies indicated that the mutagenicity of NDPhA in the presence of norharman was exerted through DPhA. The denitrosation eyzme activity of NDPhA was mainly recovered in the microsomal fraction, and the enzyme seemed to be a cytochrome P-450 monooxygenase system. Denitrosation reactions of NMPhA, NEPhA and NPhBeA were also demonstrated. The mutagenicities of these compounds with norharman are therefore suggested to be due to a mechanism similar to that of NDPhA with norharman.

LC50; Species: Daphnia magna (Water flea) age < or = 24 hr; Conditions: freshwater, static; Concentration: 7.8 mg/L for 48 hr (95% confidence interval: 5.8-11 mg/L) /> or =80% purity/

LC50; Species: Daphnia magna (Water flea) age < or = 24 hr; Conditions: freshwater, static; Concentration: >46 mg/L for 24 hr /> or =80% purity/

LC50; Species: Lepomis macrochirus (Bluegill) young of year; Conditions: freshwater, static; Concentration: 44 mg/L for 24 hr /> or =80% purity commercial grade/

LC50; Species: Lepomis macrochirus (Bluegill) young of year; Conditions: freshwater, static; Concentration: 5.8 mg/L for 96 hr (95% confidence interval: 4.8-7.6 mg/L) /> or =80% purity commercial grade/

LC50; Species: Eisenia fetida (Earthworm) adult; direct application 151 mg/kg (95% confidence interval: 136-167 mg/kg) /> or =98% purity/

TERRESTRIAL FATE: Based on a classification scheme(1), a reported Koc value of 1200(2), indicates that N-nitrosodiphenylamine is expected to have low mobility in soil(SRC). Volatilization of N-nitrosodiphenylamine from moist soil surfaces may occur(SRC) given an estimated Henry's Law constant of 1.2X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). N-Nitrosodiphenylamine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(3). N-Nitrosodiphenylamine, added to soil at a concentration of 354 ug/g soil, was degraded 68% by the end of a 30 day incubation at 30 °C in the dark(4). In soil amended with wheat straw, N-nitrosodiphenylamine disappeared completely by day 10 of the incubation(5).

AQUATIC FATE: Based on a classification scheme(1), a reported Koc value of 1200(2), indicates that N-nitrosodiphenylamine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.2X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 43 and 320 days, respectively(SRC). N-Nitrosodiphenylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), a maximum BCF of 217, measured in bluegill sunfish(6), suggests bioconcentration in aquatic organisms is high. Biodegradation was fairly rapid in a static biodegradation test that used domestic wastewater as the inoculum(7). N-Nitrosodiphenylamine biodegradation in the original culture and first, second and third subcultures after 7 days incubation per culture was: (10 mg/L initial concentration N-nitrosodiphenylamine) 47, 63, 95, and 98%; at 5 mg/L initial concentration N-nitrosodiphenylamine degradation was 87, 100, 92, and 100%, respectively(7). N-Nitrosodiphenylamine may photo-degrade in water based on structurally similar nitrosoamines that have degradation half-lives of 12-16 hours(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosodiphenylamine, which has an estimated vapor pressure of 7X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase N-nitrosodiphenylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase N-nitrosodiphenylamine may be removed from the air by wet or dry deposition(SRC). N-Nitrosodiphenylamine absorbs minimal amounts of light at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: N-nitrosodiphenylamine (NDPHA) is a solid. NDPHA is an effective radical scavenger, and can be used to stabilize monomers, polymers and petroleum products. In rubber processing, its major use is believed to be as an anti-scorching agent, or vulcanization retarder, during rubber compounding. It is also used to make p-nitrosodiphenylamine. HUMAN STUDIES: NDPHA did not induce unscheduled DNA synthesis in human foreskin fibroblasts treated with up to 400 ug/mL. ANIMAL STUDIES: In an acute study of hepatotoxicity, mice given 350 mg/kg/day of NDPHA for 4 consecutive days preceding, or one dose 24 hours prior to, pentobarbital administration had effects characteristic of liver enzyme induction. In another study, rats and mice were fed diets containing up to 46000 mg/kg NDPHA for seven or 11 weeks. Female rats did not survive doses greater than 16000 mg/kg of diet; female mice survived higher doses. Male rats and male mice were not killed by the highest doses tested (10000 and 22000 mg/kg of diet, respectively). Rats were exposed to NDPHA by dietary feed at concentrations of 0, 250, 1000, 2000, 3000 or 4000 ppm for 5 days, 2, 4 and 13 weeks duration. There were no NDPHA exposure-related clinical signs of toxicity. NDPHA at a dose of 250 ug/mL did not induce DNA repair in Escherichia coli in the presence of metabolic activation. In several studies, doses of up to 2500 ug/plate NDPHA did not induce reversions in Salmonella typhimunum strains TA98, TA100, TA1535, TA1536, TA1537, TA 1538, G46, C3076 or 03052 in the presence of metabolic activation.

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for N-nitrosodiphenylamine is available.[Available from, as of February 1, 2019: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of February 4, 2019: http://actor.epa.gov/dashboard/]

N-Nitrosodiphenylamine has been found in raw waste samples and secondary effluent samples from textiles plants in concentrations of 2-20 ug/L. It has also been found in effluents from ink manufacturing facilities(1).

N-Nitrosodiphenylamine was detected at 11 ug/L in wastewater after primary treatment and at <10 ug/L in the final effluent from the Los Angeles Joint Water Pollution Control Plant from samples collected Jul 1978(1). N-Nitrosodiphenylamine was detected in influent water samples collected from Apr to Jun 1981 from the Cedar Creek Wastewater Reclamation-Recharge Facility in Nassau County, NY at 0.8-31.8 ug/L(2). The percent removal of N-nitrosodiphenylamine from the wastewater was >94->99%(2). N-Nitrosodiphenylamine was detected in raw sludge and treated sludge, concentrations unknown, in samples taken from 37 water pollution control plants in Ontario, Canada between January and July 1986(3). N-Nitrosodiphenylamine was detected at 1100 ug/kg in sediment collected from the Iona City Landfill, Iona, MI, during September 1989(4). The concentration of N-nitrosodiphenylamine in soil/waste samples collected from the Doepke Disposal (Holiday, KS) industrial-waste landfill during 1989 was determined to be 2360 ug/kg(5). N-Nitrosodiphenylamine was detected at 0.7-147 ng/g dry weight in 79% of 74 biosolid samples collected Aug 2006 to Mar 2007 from wastewater treatment plants located in 35 US states(6).

N-Nitrosodiphenylamine

Urinary

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Nitrosamines/

For the maximum protection of human health from the potential carcinogenic effects of exposure to N-nitrosodiphenylamine through ingestion of contaminated water and contaminated aquatic organisms, the ambient water concentrations should be zero, based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, and 1X10-7. The corresponding criteria are 49,000 ng/L, 4,900 ng/L, and 490 ng/L, respectively. If these estimates are made for consumption of aquatic organisms only, excluding consumption of water, the levels are 161,00 ng/L, 16,100 ng/L, and 1,610 ng/L, respectively.

(MN) MINNESOTA 70 ug/L

(WI) WISCONSIN 7 ug/L

(FL) FLORIDA 7 ug/L

In the early 1980s, most U.S. rubber manufacturers replaced it with more efficient chemicals. Only one manufacturer in the United States produces N-nitrosodiphenylamine. [ATSDR ToxProfiles]

N-Nitrosodiphenylamine is an effective radical scavenger, and can be used to stabilize monomers, polymers and petroleum products. ln rubber processing, its major use is believed to be as an anti-scorching agent, or vulcanization retarder, during rubber compounding. It works effectively at levels of 0.5-1.0% in a variety of rubbers at processing temperatures, and does not interfere with the action of the organic accelerators at vulcanizing temperatures.

... Used as a staining retarder for natural and synthetic rubbers.

... Intermediate in the manufacture of para-nitrosodiphenylamine and as a rubber processing chemical. The Fischer-Hepp rearrangement of N-nitrosodiphenylamine can be used to produce para-nitrosodiphenylamine, which can be reduced to N-phenyl-para-phenylenediamine, a rubber-processing chemical itself and an intermediate in the manufacture of other rubber-processing chemicals.

(1977) 6.67X10+8 G

(1982) GREATER THAN 4.54X10+5 G

Synthetic production of N-nitrosamines is limited to small quantities, and the only nitrosamine produced in quantities greater than 450 kg/yr is N-nitrosodiphenylamine.

Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzenamine, N-nitroso-N-phenyl-: National Aggregate Production Volumes: 92,298 lbs (2011).

Benzenamine, N-nitroso-N-phenyl-: ACTIVE

N-Nitrosodiphenylamine has been reported to synergize the effects of halogen-containing flame retardants used in polymers but no evidence was found that it is used commercially for that purpose.