Lamotrigine → 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

HRID 449792

Reaction equation

HRID 449792 reaction equation
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[Na+].[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20].[Na+]>CO>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20]

Participants

4

Reactant 2

HCID 3878LamotrigineHCID 8736Malic acid, disodium salt

Product 1

HCID 866323236-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

20 mg of lamotrigine was dissolved in 2 ml of methanol, 12 mg of malic acid sodium salt was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

Workup

  1. customto form a single solution
  2. waitto stand for several hours
  3. customthe slow evaporation of solvent
  4. customcap vials for subsequent analysis

Sources & evidence

ORD record
ord-1bfa01b5902049028c09a97c1103eb66
Source dataset
uspto-grants-2013_07
Patent number
US08486927B2

Linked notes

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