CAS 150-90-3 Sodium Succinate (HCID 9020)

Overview

Sodium succinate (anhydrous) is an organic sodium salt that is the disodium salt of succinic acid. The hexahydrate form is used as an ingredient of topical preparations for the treatment of cataract. It contains a succinate(2-).

Names & identifiers

Preferred name: Sodium Succinate
IUPAC: disodium;butanedioate

Names & synonyms

SODIUM SUCCINATEDisodium butanedioatesuccinate sodiumButanedioic acid disodium saltSodium succinate anhydrousV8ZGC8ISR3Sodium succinate, anhydrousCHEBI:63675SODIUM SUCCINATE (MART.)SODIUM SUCCINATE [MART.]ANHYDROUS SODIUM SUCCINATE (USP-RS)ANHYDROUS SODIUM SUCCINATE [USP-RS]

Show more names

RefChem:58243Disodium succinate150-90-3Butanedioic acid, disodium saltSuccinic acid disodium saltJantaran sodnydisodium;butanedioateC4H4Na2O4

Database identifiers

CAS: 150-90-3、6106-21-4
PubChem CID: 9020
DTXSID: DTXSID5059741
ChEMBL: CHEMBL1200345、CHEMBL3907604
ChEBI: CHEBI:63675
UNII: V8ZGC8ISR3
EC Number: 205-778-7
Nikkaji: J2.965C

Properties

Computed structural propertiesFilling in

Topological polar surface area: 80.3 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 4
Rotatable bonds: 1
Heavy atoms: 10
Formal charge: 0
Complexity: 81.6

Experimental & physicochemical properties

Chemical ClassesMetals -> Organic Acids, Metal Salts

Cosmetics · 3 items

Cosmetic ingredients (Disodium Succinate) -> CIR (Cosmetic Ingredient Review)

Cosmetic ingredients (Sodium Succinate) -> CIR (Cosmetic Ingredient Review)

Buffering; Surfactant

FragrancesFragrance Ingredient (Disodium succinate) -> IFRA transparency List

Food AdditivesFLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT -> FDA Substance added to food

Flavoring AgentsEU Flavoring substances

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 83.9% (230 of 274) of all reports.

Warning

H315 (16.1%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 274 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 5 items

Chemical: Butanedioic acid, disodium salt

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Status: Active Update: 13-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/17733

Butanedioic acid, disodium salt: Does not have an individual approval but may be used under an appropriate group standard

Sodium succinate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Butanedioic acid, disodium salt: Human health tier I assessment

Hazards Summary · 1 item

Effects suggestive of kidney toxicity observed in repeated-dose oral study of rats; No evidence of reproductive or developmental toxicity in rats at doses up to 1,000 mg/kg/day; [OECD SIDS: Disodium Succinate - 2003] Safe when used as a flavoring agent in food; [EFSA] A skin and strong eye irritant; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (16.1%)

Safety & protection

Protective Action Criteria (PAC) · 3 items

15 [mg/m3]

160 [mg/m3]

970 [mg/m3]

Toxicology

Toxicity Summary · 2 items

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Chemistry & industry

Uses & manufacturing

Uses · 3 items

CIR ingredient: Disodium Succinate

CIR ingredient: Sodium Succinate

Used as an acidulant and flavoring agent for foods and as a protective coating for fruits and vegetables; [Merck Index] A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) [ChemIDplus] Used as a flavoring agent; [FDA]

Use Classification · 2 items

Fragrance Ingredients

Cosmetics -> Buffering; Surfactant

General Manufacturing InformationButanedioic acid, sodium salt (1:2): ACTIVE