Sodium Succinate → Cetirizine

HRID 390035

Reaction equation

HRID 390035 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.Cl.Cl.C(O)[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO.C([O-])(=O)CCC([O-])=O.[Na+].[Na+]>O>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 9020Sodium SuccinateHCID 55182Cetirizine HydrochlorideHCID 444041beta-Cyclodextrin

Product 1

HCID 2678Cetirizine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 65 L TK Fielder high sheer granulator equipped with a chopper is used for high shear granulation. The Cetirizine Dihydrochloride, Beta-cyclodextrin, PVP and Sodium Succinate are charged into the granulator and mixed for approximately 1 minute while with the chopper active. 1000 g of purified water is slowly added over 2 minutes while mixing and with the chopper active. The Corn Starch is then added and allowed to mix for 1 minute. The granulation is then dried in a Glatt GCPG 15 kg drying unit to a final LOD of approximately 7%.

Workup

  1. customA 65 L TK Fielder high sheer granulator equipped with a chopper
  2. additionmixed for approximately 1 minute while with the chopper active
  3. additionwhile mixing
  4. additionto mix for 1 minute
  5. customThe granulation is then dried in a Glatt GCPG 15 kg
  6. customdrying unit to a final LOD of approximately 7%

Sources & evidence

ORD record
ord-6dbe8361c7384464b9416527f2839390
Source dataset
uspto-grants-2013_02
Patent number
US08383632B2

Linked notes

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