Water → Isopropyl purine
Reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](NCC2C=CC(OC)=CC=2)[N:3]=1.[H-].[Na+].I[CH:24]([CH3:26])[CH3:25].O>CN(C=O)C>[CH:24]([C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[CH:4][N:3]=1)([CH3:26])[CH3:25]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
2-chloro-6-(4-methoxybenzylamino) purine was suspended in dry DMF (5 ml) and treated with sodium hydride, 60% dispersion (82 mg, 2.06 mmol). The suspension was stirred for 30 min over which time it became a clear yellow/green solution. 2-Iodopropane (0.280 mL, 1.7 eq.) was added over 5 min and the resultant solution stirred for 2 days. Water was added and the solution and extracted with ethyl acetate. The organic layer was evaporated to give the product isopropyl purine.
Workup
- extractionthe solution and extracted with ethyl acetate
- customThe organic layer was evaporated
Sources & evidence
- ORD record
- ord-09e947eaaa174c2c8adc53718acd6ae1
- Source dataset
- uspto-grants-2004_09
- Patent number
- US06790958B2
Reaction notes
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