2-Bromoethanol → 10-(2-hydroxyethyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane
Reaction equation
[CH2:1]1[C:3]2([CH2:11][NH:10][CH2:9][C:4]32[O:8][CH2:7][CH2:6][O:5]3)[CH2:2]1.Br[CH2:13][CH2:14][OH:15].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:15][CH2:14][CH2:13][N:10]1[CH2:11][C:3]2([CH2:1][CH2:2]2)[C:4]2([O:5][CH2:6][CH2:7][O:8]2)[CH2:9]1Participants
5
Procedure
The compound (B) (100 mg) was mixed with 2-Bromoethanol (100 mg) and K2CO3 (120 mg) in Acetonitrile. The reaction was refluxed overnight and filtered, the filtrate was evaporated and purified on silica gel column to give the titled product. Mass: (M+1), 200
Workup
- temperatureThe reaction was refluxed overnight
- filtrationfiltered
- customthe filtrate was evaporated
- custompurified on silica gel column
Sources & evidence
- ORD record
- ord-68da0bef6e6647ec8ad3506260f2ab14
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07977346B2
Reaction notes
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