Chloride → Tert-butyl 2-[5-(4-cyano-2-fluorophenyl)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]acetate

HRID 101121

Reaction equation

HRID 101121 reaction equation
[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25]([CH2:26][Zn+:27])=[O:28].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[Cl-:19].[F:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][c:9]1[CH:10]1[CH2:11][C:12](=[O:18])[c:13]2[n:14]1[cH:15][n:16][cH:17]2>>[F:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][c:9]1[CH:10]1[CH2:11][C:12]([OH:18])([CH2:26][C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:28])[c:13]2[n:14]1[cH:15][n:16][cH:17]2

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 672161543-Fluoro-4-(7-oxo-5,6-dihydropyrrolo[1,2-c]imidazol-5-yl)benzonitrileHCID 178451180HCID 178451180, compound

Product 1

HCID 77242298Tert-butyl 2-[5-(4-cyano-2-fluorophenyl)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]acetate

Sources & evidence

ORD record
ord-c27f0a75529049e080698f86745e4db5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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