Reaction equation
[CH2:1]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH2:18](Br)[CH:19]=[CH2:20].CCN(C(C)C)C(C)C.CO>CN(C=O)C.C(Cl)Cl>[CH2:20]([N:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:19]=[CH2:18]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
Vinylsulfomethylpolystyrene resin 3 (0.42 mmol g−1 (est), 160 mg) in DMF (2 cm3) was treated with dioctylamine (1.7 mmol, 515 mm3) at 20° C. for 24 h. The resin was washed with DMF (10×5 cm3) and DCM (10 cm3), resuspended in DMF (2 cm3) and treated with allyl bromide (4.25 mmol, 365 mm3) at 20° C. for 24 h. The solvent and the reagent was then removed by filtration and the resin washed with DCM (2×20 cm3). The elimination was performed in DCM (4 cm3) with DIEA (1.72 mmol, 300 mm3) overnight. The filtrate of this last reaction step was combined with the DCM and MeOH, washed (25 cm3) from the resin and evaporated. It gave 14 contaminated with DIEA in 38 mg yield. The amine was transferred in a little DCM (<5 cm3) to a K2CO3 covered dry silica column (5 g). Impurities were washed away with hexane and the amine eluted with ethyl acetate. After the removal of the solvent 14 was obtained as a colorless oil.
Workup
- washThe resin was washed with DMF (10×5 cm3) and DCM (10 cm3)
- customThe solvent and the reagent was then removed by filtration
- washthe resin washed with DCM (2×20 cm3)
- customThe filtrate of this last reaction step
- washwashed (25 cm3) from the resin
- customevaporated
Sources & evidence
- ORD record
- ord-16cd478fae0741f69f5e2b4551b2edea
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06486354B1
Linked notes
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