Potassium bis(trimethylsilyl)amide → ethyl 4-methylene-7,8-dihydro-4H-thieno[2,3-d]azepine-6(5H)-carboxylate

Temperature

0 °C

Methyl triphenylphosphonium bromide (6.3 g, 17.6 mmol) was dissolved in 150 mL THF and cooled to 0° C. KHMDS (3.2 g, 16.2 mmol) was added portionwise and the reaction was stirred for ½ hour. The product of Example 1, step (c) (3.0 g, 12.5 mmol) was added as a solution in 25 mL THF. The reaction was warmed to room temperature and stirred for 1 hour. The mixture was concentrated and the title product was purified by silica gel chromatography (0% to 40% EtOAc in hexanes) to give 2.6 g of the sub-title compound.

1. temperatureThe reaction was warmed to room temperature
2. stirringstirred for 1 hour
3. concentrationThe mixture was concentrated
4. customthe title product was purified by silica gel chromatography (0% to 40% EtOAc in hexanes)

ORD record

ord-169b7758fec74516be129d1fa1deb78f

Source dataset

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08716276B2