Hydrochloric Acid → 2-(2-Pyridyloxy)acetic acid hydrochloride

HRID 1022732

Reaction equation

HRID 1022732 reaction equation
C([O:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)(C)(C)C.[ClH:16]>C1COCC1>[ClH:16].[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][C:6]([OH:15])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46168743Tert-butyl(pyridin-2-yloxy)acetate

Product 1

HCID 669759892-(2-Pyridyloxy)acetic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tert-butyl(pyridin-2-yloxy)acetate (0.18 g) in THF (1.5 mL) was added 6 mol/L hydrochloric acid (1.5 mL) at 0° C., and the mixture was warmed to room temperature, and stirred for 2 hr. The solvent was evaporated under reduced pressure, and the resultant solid was recrystallized from ethyl acetate and diisopropyl ether to give the title compound (0.11 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resultant solid was recrystallized from ethyl acetate and diisopropyl ether

Sources & evidence

ORD record
ord-f42aa198ffd049f88bb95d785cff233c
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Linked notes

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