4-Toluenesulfonyl chloride → p-Toluenesulfonamide, N-benzyl-

HRID 1031283

Reaction equation

HRID 1031283 reaction equation
Cc1ccc(S(=O)(=O)Cl)cc1.NCc1ccccc1>CC(C)=O.O.O=C([O-])O.OCCOCCOCCOCCOCCO.[Na+]>Cc1ccc(S(=O)(=O)NCc2ccccc2)cc1

Participants

7

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 7504Benzylamine

Product 1

HCID 95801p-Toluenesulfonamide, N-benzyl-Yield 100%

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 180AcetoneSolventHCID 962WaterSolventHCID 62551Pentaethylene glycolSolvent

Conditions

Temperature
25 °C

Workup

  1. additionNo procedure recorded
  2. extractionKeep organic
  3. washNo procedure recorded
  4. washNo procedure recorded
  5. dry with materialNo procedure recorded
  6. concentrationNo procedure recorded

Sources & evidence

ORD record
ord-d2c4ec0927a44a2b8b90f7ace120ecf4
Source dataset
39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
Original link
View source

Linked notes

Loading…