Methacrylamide → Ethyl [(2-methylacryloyl)amino](oxo)acetate
Reaction equation
[C:1]([NH2:6])(=[O:5])[C:2]([CH3:4])=[CH2:3].[C:7](Cl)([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:8]>O1CCCC1>[C:7]([NH:6][C:1](=[O:5])[C:2]([CH3:4])=[CH2:3])([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Into the same reaction vessel as used in Example 1, tetrahydrofuran (50 ml), methacrylamide (4.26 g; 50 mmol) and ethoxalyl chloride (6.83 g; 50 mmol) were charged, and refluxing was continued for 4 hours. Removal of the organic solvent by distillation under reduced pressure gave N-ethoxalylmethacrylamide (6.5 g). Yield, 70.6%.
Workup
- additionwere charged
- temperaturerefluxing
- customRemoval of the organic solvent
- distillationby distillation under reduced pressure
Sources & evidence
- ORD record
- ord-38cc584a885647a3bda0cb1186226acd
- Source dataset
- uspto-grants-1990_09
- Patent number
- US04956491
Reaction notes
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