Ethyl Acetate → HCID 55281286, compound

HRID 1039121Notes

Reaction equation

HRID 1039121 reaction equation
[NH:1]([C:3](=[S:6])OC)[NH2:2].[NH:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1.C(OCC)(=O)C>C(O)C>[NH:1]([C:3]([N:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1)=[S:6])[NH2:2]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 79341Piperidin-4-olHCID 10171237O-methyl hydrazinecarbothioate

Product 1

HCID 55281286HCID 55281286, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A solution of methyl hydrazinecarbothioate (1.0 g, 8.2 mmol) and piperidin-4-ol (1.24 g, 12.3 mmol) in ethanol (7 mL) was refluxed with heating at 90° C. for 2 days. After addition of ethyl acetate, the reaction solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product. The crude product was used directly for the next reaction.

Workup

  1. washthe reaction solution was washed with saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-ffdf41338bfb4baf90c4987ed35a4d2c
Source dataset
uspto-grants-2013_10
Patent number
US08552031B2

Reaction notes

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