Lithium Hydroxide → 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid
Reaction equation
C[O:2][C:3](=[O:18])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[O:13][CH:14]([CH2:16][CH3:17])[CH3:15].[Li+].[OH-]>C1COCC1.CO>[CH:14]([O:13][C:7]1[CH:8]=[C:9]([F:12])[CH:10]=[CH:11][C:6]=1[CH:5]=[CH:4][C:3]([OH:18])=[O:2])([CH2:16][CH3:17])[CH3:15]Participants
5
Procedure
3-(2-sec-Butoxy-4-fluoro-phenyl)-acrylic acid methyl ester (105 mg) was reacted with 1N LiOH (5 ml) in THF and CH3OH for 2 hrs as described above to yield title compound (82 mg)
Sources & evidence
- ORD record
- ord-a01978779a544175bc7cb2aa2166718a
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08557872B2
Reaction notes
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