Potassium Carbonate → HCID 58306160, compound

To a solution of 2-[(1-methylethyl)oxy]-8-(methyloxy)-1H-purin-6-amine (37 mg, 0.166 mmol) in DMF (0.5 ml) was added potassium carbonate (55 mg, 0.398 mmol) followed by a solution of 1,1-dimethylethyl 4-(4-bromobutyl)-1-piperidinecarboxylate (58 mg, 0.181 mmol) in DMF (0.2 ml) and the mixture was stirred at room temperature for 72 hours. The mixture was diluted with dichloromethane (5 ml) and washed with water (5 ml). The layers were separated using a hydrophobic frit, the aqueous layer was extracted again with dichloromethane (5 ml) and the combined organic extracts were evaporated. The residue was dissolved in methanol (0.6 ml) and purified by MDAP (Method A). The appropriate fractions were combined and evaporated under a stream of nitrogen in a blowdown apparatus to give the title compound as a colourless gum (32 mg).

1. washwashed with water (5 ml)
2. customThe layers were separated
3. extractionthe aqueous layer was extracted again with dichloromethane (5 ml)
4. customthe combined organic extracts were evaporated
5. dissolutionThe residue was dissolved in methanol (0.6 ml)
6. custompurified by MDAP (Method A)
7. customevaporated under a stream of nitrogen in a blowdown apparatus

ORD record

ord-282046417d3d473884a9c69f4dcf45a9

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08563717B2