Tetrahydrofuran → 3-[(3-Formyl-pyridin-4-yl)-hydroxy-methyl]-benzonitrile

HRID 105019

Reaction equation

HRID 105019 reaction equation
[C:14](#[N:15])[c:16]1[cH:17][c:18]([CH:19]=[O:20])[cH:21][cH:22][cH:23]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[n:6]1[cH:7][c:8]([CH:12]=[O:13])[cH:9][cH:10][cH:11]1>>[n:6]1[cH:7][c:8]([CH:12]=[O:13])[c:9]([CH:19]([c:18]2[cH:17][c:16]([C:14]#[N:15])[cH:23][cH:22][cH:21]2)[OH:20])[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 103713-PyridinecarboxaldehydeHCID 90670m-FormylbenzonitrileHCID 178418339Butyllithium

Product 1

HCID 866112583-[(3-Formyl-pyridin-4-yl)-hydroxy-methyl]-benzonitrile

Sources & evidence

ORD record
ord-d67c9d30c3fd40bfae46642849c3bc3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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