Diethylamine → (2,2-Diethoxyethyl)diethylamine
Reaction equation
Br[CH2:2][CH:3]([O:7][CH2:8][CH3:9])[O:4][CH2:5][CH3:6].[CH2:10]([NH:12][CH2:13][CH3:14])[CH3:11]>CC(C)=O>[CH2:5]([O:4][CH:3]([O:7][CH2:8][CH3:9])[CH2:2][N:12]([CH2:13][CH3:14])[CH2:10][CH3:11])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-bromo-1,1-diethoxyethane (10 g, 0.051 mol), diethylamine (11 g, 0.15 mol) and KI (8.5 g, 0.051 mol) were added in 100 mL acetone, and stirred for overnight at 40 degree. The resulting solution was filtered, concentrated and purified with silica gel column to give 2,2-diethoxy-N,N-diethylethanamine as brown oil 2.0 g (20.8% yield).
Workup
- filtrationThe resulting solution was filtered
- concentrationconcentrated
- custompurified with silica gel column
Sources & evidence
- ORD record
- ord-1d05ce371e2c4dfb971a0a1523dbdd3f
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09388170B2
Reaction notes
Loading…