Piperidine → (S)-2-((E)-3-aminoprop-1-enyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-5,11-dioxo-10-((2-(trimethylsilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yloxy)propoxy)-10-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione
Reaction equation
N1CCCCC1.[CH3:7][O:8][C:9]1[C:53]([O:54][CH2:55][CH2:56][CH2:57][O:58][C:59]2[C:60]([O:96][CH3:97])=[CH:61][C:62]3[C:68](=[O:69])[N:67]4[CH:70]=[C:71]([C:73]5[CH:78]=[CH:77][C:76]([N:79]6[CH2:84][CH2:83][N:82]([CH3:85])[CH2:81][CH2:80]6)=[CH:75][CH:74]=5)[CH2:72][C@H:66]4[C:65](=[O:86])[N:64]([CH2:87][O:88][CH2:89][CH2:90][Si:91]([CH3:94])([CH3:93])[CH3:92])[C:63]=3[CH:95]=2)=[CH:52][C:12]2[N:13]([CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:51])([CH3:50])[CH3:49])[C:14](=[O:43])[C@@H:15]3[CH2:21][C:20](/[CH:22]=[CH:23]/[CH2:24][NH:25]C(=O)OCC4C5C=CC=CC=5C5C4=CC=CC=5)=[CH:19][N:16]3[C:17](=[O:18])[C:11]=2[CH:10]=1>CN(C=O)C.C(Cl)Cl>[NH2:25][CH2:24]/[CH:23]=[CH:22]/[C:20]1[CH2:21][C@H:15]2[C:14](=[O:43])[N:13]([CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:50])([CH3:51])[CH3:49])[C:12]3[CH:52]=[C:53]([O:54][CH2:55][CH2:56][CH2:57][O:58][C:59]4[C:60]([O:96][CH3:97])=[CH:61][C:62]5[C:68](=[O:69])[N:67]6[CH:70]=[C:71]([C:73]7[CH:74]=[CH:75][C:76]([N:79]8[CH2:84][CH2:83][N:82]([CH3:85])[CH2:81][CH2:80]8)=[CH:77][CH:78]=7)[CH2:72][C@H:66]6[C:65](=[O:86])[N:64]([CH2:87][O:88][CH2:89][CH2:90][Si:91]([CH3:92])([CH3:94])[CH3:93])[C:63]=5[CH:95]=4)[C:9]([O:8][CH3:7])=[CH:10][C:11]=3[C:17](=[O:18])[N:16]2[CH:19]=1Participants
5
Reactant 2
HCID 8082Piperidine
HCID 1317364549H-fluoren-9-ylmethyl N-[(E)-3-[(6aS)-3-[3-[[(6aS)-2-methoxy-8-[4-(4-methylpiperazin-1-yl)phenyl]-6,11-dioxo-5-(2-trimethylsilylethoxymethyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-6,11-dioxo-5-(2-trimethylsilylethoxymethyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-8-yl]prop-2-enyl]carbamateProduct 1
