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Hydrochloric Acid → N-{2-[4-(3,4-Dichlorobenzoyl)-1-piperazinyl]ethyl}-3-methoxybenzamide hydrochloride

HRID 1059020
Notes
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Reaction equation

HRID 1059020 reaction equation
FC(F)(F)C(O)=O.[NH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=2)=[O:18])[CH2:13][CH2:12]1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](Cl)=[O:33].O.Cl>N1C=CC=CC=1.C(OCC)(=O)C>[ClH:25].[Cl:26][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][C:22]=1[Cl:25])[C:17]([N:14]1[CH2:15][CH2:16][N:11]([CH2:10][CH2:9][NH:8][C:32](=[O:33])[C:31]2[CH:35]=[CH:36][CH:37]=[C:29]([O:28][CH3:27])[CH:30]=2)[CH2:12][CH2:13]1)=[O:18]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 74374m-Anisoyl chlorideHCID 22322358[4-(2-Aminoethyl)-1-piperazinyl](3,4-dichlorophenyl)methanone trifluoroacetate

Product 1

HCID 22322220N-{2-[4-(3,4-Dichlorobenzoyl)-1-piperazinyl]ethyl}-3-methoxybenzamide hydrochloride

Reagents, catalysts & solvents 2

HCID 1049
Pyridine
Solvent
HCID 8857Ethyl AcetateSolvent

Procedure

The product from step (iii) above (0.15 g) was dissolved in pyridine (2 ml) and 3-methoxybenzoyl chloride (0.064 g) added. After 16 hours at room temperature, water and ethyl acetate were added, the organic phase separated, dried and concentrated to an oil. Purification by chromatography (dichloromethane:methanol, 95:5) gave an oil which was treated with 1.0M ethereal hydrogen chloride solution to give the titled product as a solid (0.043 g).

Workup

  1. customthe organic phase separated
  2. customdried
  3. concentrationconcentrated to an oil
  4. customPurification by chromatography (dichloromethane:methanol, 95:5)
  5. customgave an oil which

Sources & evidence

ORD record
ord-7ca1e72a502b4f28965df5234c77c532
Source dataset
uspto-grants-2003_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06518286B1

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes