HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Potassium Carbonate → 2,5,6,7-Tetrahydro-1-thia-2,6-diaza-cyclopenta[cd]phenalene 1,1-dioxide

HRID 1068563
Notes
Print preview

Reaction equation

HRID 1068563 reaction equation
C(=O)([O-])[O-].[K+].[K+].[N+]([C:10]1[C:11]2[C:12]3[C:17](=[CH:18][CH:19]=1)[CH2:16][NH:15][CH2:14][C:13]=3[CH:20]=[CH:21][C:22]=2[S:23]([NH2:26])(=[O:25])=[O:24])([O-])=O>CN(C=O)C>[S:23]1(=[O:24])(=[O:25])[C:22]2[CH:21]=[CH:20][C:13]3[CH2:14][NH:15][CH2:16][C:17]4[C:12]=3[C:11]=2[C:10](=[CH:19][CH:18]=4)[NH:26]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 206661157-nitro-2,3-dihydro-1H-Benz[de]isoquinoline-6-sulfonic acid amide

Product 1

HCID 206661122,5,6,7-Tetrahydro-1-thia-2,6-diaza-cyclopenta[cd]phenalene 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Potassium carbonate (15 mmol) is added to a solution of 7-nitro-2,3-dihydro-1H-Benz[de]isoquinoline-6-sulfonic acid amide (3 mmol) in anhydrous DMF (30 mL). The resulting solution is stirred at 100° C. for 12 hours then partitioned between ethyl acetate and water. The organic layer is dried over magnesium sulfate and concentrated to afford the title compound. The crude product can be purified by recrystallization or chromatography.

Workup

  1. customthen partitioned between ethyl acetate and water
  2. dry with materialThe organic layer is dried over magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b828aa2a11a24131808d2991bdee17e2
Source dataset
uspto-grants-2001_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06251890B1

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes