Hydrochloric Acid → 1-Butyl-4-(3-trifluoromethyl-phenyl)piperidine

Reaction equation

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH2:17](Br)[CH2:18][CH2:19][CH3:20].Cl>>[CH2:17]([N:12]1[CH2:11][CH2:10][CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:14][CH2:13]1)[CH2:18][CH2:19][CH3:20]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 8002Butyl bromide

HCID 117363404-(3-(Trifluoromethyl)Phenyl)Piperidine

Product 1

HCID 223978491-Butyl-4-(3-trifluoromethyl-phenyl)piperidine

Procedure

Beginning with 4-(3-Trifluoromethyl-phenyl)-piperidine and n-Bu-Br: m.p. 222° C. (HCl), MS m/z (rel. intensity, 70 eV) 285 (M+, 3), 243 (12), 242 (bp), 70 (51), 56 (17).

Sources & evidence

ORD record: ord-cbc8b76f2ff04511a45234e682301cd5
Source dataset: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06903120B2

Reaction notes

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