Ethylene carbonate → 2-(5-Fluoro-2-methoxyphenoxy)ethanol
Reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.C1(=O)O[CH2:14][CH2:13][O:12]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][CH2:14][CH2:13][OH:12]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
A suspension of 8.75 g of 5-fluoro-2-methoxyphenol, 10.9 g of ethylene carbonate and 8.50 g of potassium carbonate in 12 ml of toluene was refluxed for 2.5 hours. The reaction mixture was diluted with benzene, washed with water, dried and evaporated. The residue was distilled to give 9.15 g of 2-(5-fluoro-2-methoxyphenoxy)ethanol as colorless oil, b.p. 138°-140° C. (8mmHg).
Workup
- temperaturewas refluxed for 2.5 hours
- washwashed with water
- customdried
- customevaporated
- distillationThe residue was distilled
Sources & evidence
- ORD record
- ord-b9a9945b2083473f800340acad563587
- Source dataset
- uspto-grants-1990_11
- Patent number
- US04971990
Reaction notes
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