Tetrahydrofuran → 1-(2,4-difluorophenyl)-N-ethyl-1H-pyrazol-5-amine

Reaction equation

[Al+3:19].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[F:1][c:2]1[c:3](-[n:9]2[n:10][cH:11][cH:12][c:13]2[NH:14][C:15]([CH3:16])=[O:17])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[H-:18].[H-:21].[H-:22].[H-:23].[Li+:20]>>[F:1][c:2]1[c:3](-[n:9]2[n:10][cH:11][cH:12][c:13]2[NH:14][CH2:15][CH3:16])[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 67199804N-(1-(2,4-difluorophenyl)-1H-pyrazol-5-yl)acetamide

Product 1

HCID 671980121-(2,4-difluorophenyl)-N-ethyl-1H-pyrazol-5-amine

Sources & evidence

ORD record: ord-172ebf9769004308baa1e55c450aab6b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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