Lithium sulfate → Glucosamine sulfate lithium chloride

HRID 1075439

Reaction equation

HRID 1075439 reaction equation
[ClH:1].[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].[S:14]([O-:18])([O-:17])(=[O:16])=[O:15].[Li+:19].[Li+]>O>[Cl-:1].[Li+:19].[S:14]([OH:18])([OH:17])(=[O:16])=[O:15].[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5]

Participants

4

Reactant 2

HCID 66320Lithium sulfateHCID 2723635(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride

Product 1

HCID 86754062Glucosamine sulfate lithium chloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Example 1 was repeated using 1679 g of purified water, 431.5 g (2 moles) of glucosamine hydrochloride and 128 g (1 mole) of lithium sulfate (monohydrate) instead of the sodium sulfate. After freeze drying, glucosamine sulfate lithium chloride was obtained as a white powder in a yield of 525 g (97% of theoretical).

Workup

  1. customAfter freeze drying

Sources & evidence

ORD record
ord-936ee2068b904d9798f028b3ea0fbb36
Source dataset
uspto-grants-1999_05
Patent number
US05902801

Linked notes

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