Potassium Carbonate → Ethyl 2-(hydroxyimino)-3-(4,6-dibromo-3-indolyl)propanoate

Mix 4,6-dibromoindole (2.09 g, 7.58 mmol), potassium carbonate (1.57 g, 11.4 mmol) and anhydrous methylene chloride (30 mL). Stir and add a solution of ethyl 3-bromo-2-hydroxyiminopropanoate (1.59 g, 7.58 mmol) in methylene chloride (20 mL). Stir under a nitrogen atmosphere for 48 hours. Take the solution up in ethyl acetate and wash with water (100 mL), saturated sodium hydrogen carbonate (100 mL) and brine (100 mL). Dry (MgSO4) and evaporate the solvent in in vacuo and purify by silica gel chromatography to give the title compound.

1. stirringStir under a nitrogen atmosphere for 48 hours
2. washwash with water (100 mL), saturated sodium hydrogen carbonate (100 mL) and brine (100 mL)
3. dry with materialDry (MgSO4)
4. customevaporate the solvent in in vacuo
5. custompurify by silica gel chromatography

ORD record

ord-f1eb71ad1c784e6f88143e9074caa719

Source dataset

uspto-grants-1996_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05547991