1-Methyl-2-(propan-2-yl)-1H-imidazole → HCID 178440022, compound

HRID 1082826Notes

Reaction equation

HRID 1082826 reaction equation
CC(C)(C)NS(=O)(=O)c1cncc(Br)c1.CC(C)c1nccn1C>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=C(c1ccccc1)c1ccccc1)P(C1CCCCC1)C1CCCCC1.CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+]>CC(C)c1ncc(-c2cncc(S(=O)(=O)NC(C)(C)C)c2)n1C

Participants

8

Reactant 2

HCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazoleHCID 617949515-Bromo-N-tert-butylpyridine-3-sulfonamide

Product 1

HCID 178440022HCID 178440022, compoundYield 73.61%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 12010824Cy-vBRIDPCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-e364dc217c5a43e19348f05099ee1f43
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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