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1-Benzyl-2,4-dimethyl-1H-imidazole → HCID 178468644, compound

HRID 1083087
Notes
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Reaction equation

HRID 1083087 reaction equation
CCOC(=O)c1cc(Br)cn1CC.Cc1cn(Cc2ccccc2)c(C)n1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CCCCC1(P(C2CCCCC2)C2CCCCC2)c2ccccc2-c2ccccc21.[K+]>CCOC(=O)c1cc(-c2c(C)nc(C)n2Cc2ccccc2)cn1CC
ParticipantsConditionsWorkupSources & evidenceReaction notes

Participants

8

Reactant 2

HCID 147449731-Benzyl-2,4-dimethyl-1H-imidazoleHCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 178468644HCID 178468644, compoundYield 0.34%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 71310598(9-Butylfluoren-9-yl)-dicyclohexylphosphaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-c6834bb12dc24148beb75fcd7c0ca57f
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
DOI
10.26434/chemrxiv
Original link
View source

Reaction notes

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On this pageParticipantsConditionsWorkupSources & evidenceReaction notes