Triethylamine → Diethyl 3-tert.butyl-2-isoxazolin-5-ylphosphonate

HRID 1084800

Reaction equation

HRID 1084800 reaction equation
[CH:1](=[N:6][OH:7])[C:2]([CH3:5])([CH3:4])[CH3:3].ClN1C(=O)CCC1=O.[CH:16]([P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH2:17].C(N(CC)CC)C>ClCCl.N1C=CC=CC=1>[C:2]([C:1]1[CH2:17][CH:16]([P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])[O:7][N:6]=1)([CH3:5])([CH3:4])[CH3:3]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 31398ChlorosuccinimideHCID 69629Diethyl vinylphosphonateHCID 136457Pivalaldoxime

Product 1

HCID 86744708Diethyl 3-tert.butyl-2-isoxazolin-5-ylphosphonate

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

The procedure is analogous to that of Example 25 using 15.2 g (0.15 mol) of pivalaldoxime, 22.0 g (0.165 mol) of N-chlorosuccinimide, 0.5 ml of pyridine, 27.1 g (0.165 mol) of diethyl vinylphosphonate and 22.9 ml (0.165 mol) of triethylamine in dichloromethane. The product is obtained as an oil after the usual working up.

Workup

  1. customThe product is obtained as an oil after the

Sources & evidence

ORD record
ord-f7ff29b72e2e4375b1d0bcfc664d7b01
Source dataset
uspto-grants-1991_04
Patent number
US05006515

Linked notes

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