Stannous Chloride → 2-Chloro-4-hydrazinylbenzonitrile hydrochloride
Reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[CH:3]=1.[N:11]([O-])=O.[Na+].Cl[Sn]Cl>C1COCC1.O.Cl>[ClH:10].[Cl:10][C:4]1[CH:3]=[C:2]([NH:1][NH2:11])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]Participants
7
Conditions
- Temperature
- -5 °C
Procedure
5 g of 4-amino-2-chlorobenzonitrile and 40 ml of concentrated HCl in 30 ml of THF are mixed at -5° C.; 2.26 g of NaNO2 in 30 ml of water are added and the mixture is left stirring for 2 hours, 30 g of SnCl2 ·2H2O in 30 ml of concentrated HCl are then added and stirring is maintained at -5° C. for 30 minutes.
Workup
- waitthe mixture is left
- stirringstirring
Sources & evidence
- ORD record
- ord-951984be58214825afaa7f028775b4b9
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723483
Reaction notes
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