4-Methoxyphenol → HCID 57743277, compound
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)=[C:6]([CH:9]=1)[CH:7]=[O:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (2.1 g, 10 mmol) (Alfa) was reacted with 4-methoxyphenol (1.24 g, 10 mmol) and K2CO3 in N,N-dimethylacetamide to give 5-bromo-2-(4-methoxy-phenoxy)-benzaldehyde as a white solid (Yield 3.1 g, 92%).
Sources & evidence
- ORD record
- ord-84b9636194bf445f96309676bceb2863
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08134001B2
Reaction notes
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