Potassium Carbonate → 5-Chloro-2-(tetrahydro-thiopyran-4-yloxy)-benzaldehyde

HRID 1095191

Reaction equation

HRID 1095191 reaction equation
[Cl:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.[S:11]1[CH2:16][CH2:15][CH:14](OS(C)(=O)=O)[CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:14]2[CH2:15][CH2:16][S:11][CH2:12][CH2:13]2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 124815-Chloro-salicylaldehydeHCID 124202654-(Methanesulfonyl)oxytetrahydrothiopyran

Product 1

HCID 577432645-Chloro-2-(tetrahydro-thiopyran-4-yloxy)-benzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a manner similar to the method described in Example 4a, 5-chloro salicylaldehyde (Aldrich) reacted with methanesulfonic acid tetrahydro-thiopyran-4-yl ester prepared in Example 130a and potassium carbonate in dimethylformamide to give a solid. MS (H+), 257.

Workup

  1. customto give a solid

Sources & evidence

ORD record
ord-4020dd438f384995976b783ec79de911
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Linked notes

Loading…