Toluene → 4-Chloro-5,7-dimethoxyquinoline

Reaction equation

[CH3:1][O:2][c:3]1[c:4]2[c:5]([OH:15])[cH:6][cH:7][n:8][c:9]2[cH:10][c:11]([O:13][CH3:14])[cH:12]1.[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[CH:16]([N:17]([CH2:18][CH3:19])[CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[P:25]([Cl:26])([Cl:27])([Cl:28])=[O:29]>>[CH3:1][O:2][c:3]1[c:4]2[c:5]([Cl:27])[cH:6][cH:7][n:8][c:9]2[cH:10][c:11]([O:13][CH3:14])[cH:12]1

Participants

Reactant 4

HCID 1140Toluene

HCID 24813Phosphorus oxychloride

HCID 81531Diisopropylethylamine

HCID 178493398HCID 178493398, compound

Product 1

HCID 178804724-Chloro-5,7-dimethoxyquinoline

Sources & evidence

ORD record: ord-1e90f47c3bb541568f642603774495cb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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